Thrombus formation can lead to heart attacks, stroke and pulmonary embolism, which are major causes of mortality. Current standard diagnostic imaging methods detect anatomic abnormalities such as vascular flow impairment but have limitations. By using a targeted molecular imaging approach critical components of a pathology can be selectively visualized and exploited for an improved diagnosis and patient management.
Life Molecular Imaging and its collaboration partners are investigating 18F-GP1, a small fluorine-18-labeled molecule. It binds with high affinity to activated GPIIb/IIIa receptors, which represent one of the key processes in thrombus formation and progression. 18F-GP1 is the first PET tracer that demonstrated the ability to detect acute thromboembolic events in patients.
Preclinical and initial clinical results from a Phase 1 study have been published recently and were also selected as featured articles in the July issue of JNM in 2017 and in the February issue of JNM in 2019:
Source: Journal of Nuclear Medicine Cover Image, February 1, 2019; 60 (2). The cover image is artwork presented in
Source: Journal of Nuclear Medicine Cover Image, July 1, 2017; 58(7). The cover image is artwork presented in Lohrke et al. (2017) reporting about “18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi”
For additional information see also the accompanying SNMMI press release.
Selected publications on 18F-GP1:
- Chae SY et al. (2019) A phase 1, first-in-human study of 18F-GP1 positron emission tomography for imaging acute arterial thrombosis. EJNMMI Res. 2019 Jan 7;9(1):3
- Kim C. et al. (2018) Glycoprotein IIb/IIIa receptor imaging with 18F-GP1 positron emission tomography for acute venous thromboembolism: an open-label, non-randomized, first-in-human phase 1 study. J Nucl Med. 2019 Feb;60(2):244-249.
- Stephens AW et al. (2018) Commentary to 18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi: Imaging Activated Platelets in Clots-Are We Getting There? Mol Imaging. 2018 Jan-Dec; 17:1-4.
- Lohrke J et al. (2017) 18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi. J Nucl Med. 2017 Jul;58(7):1094-1099. https://www.ncbi.nlm.nih.gov/pubmed/28302764